Mechanisms of Renal Microvascular Dysfunction in Type 1 Diabetes: Potential Contribution to End Organ Damage
Pamela K. Carmines.
The mechanisms underlying initiation and progression of diabetic nephropathy are not well understood, despite
the fact that diabetes represents the chief underlying cause of end-stage renal disease. The onset of diabetic hyperglycemia
is now known to evoke functional alterations in the renal microvasculature, glomeruli and tubular epithelium. Although
the scope of these effects is not yet fully recognized, the renal vascular dysfunction evident early after onset of T1D likely
encompasses impaired electromechanical coupling in preglomerular vascular smooth muscle and altered interactions between
tubular transport and vascular function. These changes, which arise in environment conducive to oxidative stress
and inflammation, are thought to either initiate or facilitate the eventual development of diabetic nephropathy in susceptible
Keywords: Afferent arteriole, autoregulation, C-peptide, diabetes mellitus, K+ channels, oxidative stress.
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