Impaired Renal Autoregulation in Susceptible Models of Renal Disease
Jan M. Williams.
One of the major functions of the kidney is to maintain constant renal blood flow and glomerular filtration rate
in response to increases in renal perfusion pressure. This phenomenon is referred to autoregulation and involves two independent
mechanisms: tubular glomerular feedback and myogenic response. The latter, the renal myogenic response, involves
constriction of the preglomerular vasculature to increases in transmural pressure. Over the last three decades, there
has been substantial evidence that demonstrates that the myogenic response plays an important role in protecting the kidney
from hypertension-induced renal injury. Furthermore, impairment of the renal myogenic response allows the transmission
of systemic pressures to the glomerular capillaries leading to the development of glomerular injury and progressive
proteinuria during hypertension. This review article discusses the role of the myogenic response in the pathogenesis
of renal disease in various genetic and experimental rodent models that develop hypertension-induced renal injury.
Keywords: Autoregulation, glomerulosclerosis, glomerular capillary pressure, renal blood flow.
Rights & PermissionsPrintExport