Key Role of Mitochondria in Alzheimer’s Disease Synaptic Dysfunction

Author(s): Virve Cavallucci , Caterina Ferraina , Marcello D'Amelio .

Journal Name: Current Pharmaceutical Design

Volume 19 , Issue 36 , 2013

Abstract:

Neuronal transmission and functional synapses require mitochondria, which are mainly involved in the generation of energy (ATP and NAD+), regulation of cell signaling and calcium homeostasis. Particularly intriguing is emerging data suggesting the relationship between mitochondria and neurotrophic factors that can act at the synaptic level promoting neuronal transmission and plasticity. On the other hand, disturbances in mitochondrial functions might contribute to impaired synaptic transmission and neuronal degeneration in Alzheimer’s Disease and other chronic and acute neurodegenerative disorders. Here, we review the molecular mediators controling mitochondrial function and their impact on synaptic dysfunction associated with the pathogenesis of Alzheimer’s Disease.

Keywords: Cell death, mitochondria dynamics, apoptosis, ATP production, neurotransmitter release, synaptic function.

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Article Details

VOLUME: 19
ISSUE: 36
Year: 2013
Page: [6440 - 6450]
Pages: 11
DOI: 10.2174/1381612811319360005
Price: $58

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