Computational Studies on the Prion Protein

Author(s): Giulia Rossetti, Salvatore Bongarzone, Paolo Carloni.

Journal Name: Current Topics in Medicinal Chemistry

Volume 13 , Issue 19 , 2013

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Abstract:

Prion diseases are rare neurodegenerative diseases characterized by the conversion of the prion protein from its native state (PrPC) towards the so-called 'scrapie form', rich in β-strands. Computational approaches, here briefly reviewed, are instrumental to understand the intrinsic instability of PrPC fold and how the latter is affected by mutations, binding of metals as well as by different environmental conditions, such as pH and temperature. These studies also provide a structural basis for the binding of anti-prion compounds, which may block the conversion to the scrapie form and, consequently, may inhibit fibril formation.

Keywords: Prion proteins, native state, scrapie form, molecular simulation, bioinformatics, molecular docking.

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Article Details

VOLUME: 13
ISSUE: 19
Year: 2013
Page: [2419 - 2431]
Pages: 13
DOI: 10.2174/15680266113136660170
Price: $58

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