Letters in Organic Chemistry

Gwilherm Evano
Free University of Brussels


Synthesis and Single-Crystal X-Ray Diffraction Studies of an Arylidenethiosemicarbazone and Hydrazonyl-phenylthiazole

Author(s): El Sayed H. El Ashry, Sammer Yousuf, Hayat H. Hassan, Magdy K. Zahran, Ali S. Hebishy.


The reaction of aromatic aldehydes with thiosemicarbazide gives arylidene hydrazinecarbothioamide, whose reaction with phenacyl bromide, yielded (arylidenehydrazonyl)-4-phenylthiazole. The structures of 3 and 7 were fully characterized by using 1H-NMR and mass spectroscopic techniques. The spectral analysis agreed with the assigned structures. The assigned structures were further supported by single-crystal X-ray diffraction studies and summarized as follows: (3) Triclinic, P-1, a=7.6319(4) Å, b= 8.7099(4) Å, c=10.7145(5) Å, α= 77.7400 (10)°, β= 74.0160 (10)°, and γ= 72.8270 (10)°, V= 647.47(5) Å3, and Z = 2; (7) Orthorhombic, Pna21, a = 9.3760(13), b = 14.029(2), c = 23.591(3)Å, α=90, β= 90, and γ= 90o, V = 3103.0(7)Å3, and Z = 4.

Keywords: Thiosemicarbazone, phenylthiazole, x-ray, geometric isomers, hydrazonylthiazole, phenacyl bromide.

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Article Details

Year: 2014
Page: [101 - 108]
Pages: 8
DOI: 10.2174/15701786113106660065
Price: $58