Letters in Organic Chemistry

Miguel Yus  
Universidad de Alicante Apdo


Synthesis and Single-Crystal X-Ray Diffraction Studies of an Arylidenethiosemicarbazone and Hydrazonyl-phenylthiazole

Author(s): El Sayed H. El Ashry, Sammer Yousuf, Hayat H. Hassan, Magdy K. Zahran and Ali S. Hebishy

Affiliation: International Center for Chemical and Biological Science, H.E.J. Research Institute of Chemistry, University of Karachi, Karachi, Pakistan.


The reaction of aromatic aldehydes with thiosemicarbazide gives arylidene hydrazinecarbothioamide, whose reaction with phenacyl bromide, yielded (arylidenehydrazonyl)-4-phenylthiazole. The structures of 3 and 7 were fully characterized by using 1H-NMR and mass spectroscopic techniques. The spectral analysis agreed with the assigned structures. The assigned structures were further supported by single-crystal X-ray diffraction studies and summarized as follows: (3) Triclinic, P-1, a=7.6319(4) Å, b= 8.7099(4) Å, c=10.7145(5) Å, α= 77.7400 (10)°, β= 74.0160 (10)°, and γ= 72.8270 (10)°, V= 647.47(5) Å3, and Z = 2; (7) Orthorhombic, Pna21, a = 9.3760(13), b = 14.029(2), c = 23.591(3)Å, α=90, β= 90, and γ= 90o, V = 3103.0(7)Å3, and Z = 4.

Keywords: Thiosemicarbazone, phenylthiazole, x-ray, geometric isomers, hydrazonylthiazole, phenacyl bromide.

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Article Details

Page: [101 - 108]
Pages: 8
DOI: 10.2174/15701786113106660065