The following review analyzes the most effective activation protocols for the generation of transient electrophilic quinone
methides, merged into the recent strategies to achieve recognition and alkylation of nucleic acids. The covalent targeting has to be specific
for selected oligonucleotide sequences (sequence-specificity) or for those oligonucleotides capable to fold into supramolecular structures,
such as G-quadruplexes (structure-specificity). The reversibility of the DNA alkylation process by QM is reviewed underlining the
opportunities (in term of selectivity and delivery) and drawbacks (in term of product characterization of the covalent damage) in the DNA
Keywords: Alkylation, cross-linking, nucleic acids, quinone methides, reversibility, sequence-specificity, structure-specificity.
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