Manganese Superoxide Dismutase Gene Therapy Protects Against Irradiation- Induced Intestinal Injury
Radiation-induced intestinal injury is a common complication in radiotherapy for solid organ malignancies in
abdomen or pelvis. However, currently there are no approved medical countermeasures for radiation-induced intestinal injury.
Therefore, it is urgent to develop new treatments for radiation-induced intestinal injury. In the present study, we
demonstrated that bone marrow derived mesenchymal stem cells (MSCs) and overexpression of human manganese superoxide
dismutase (MnSOD) could ameliorate radiation-induced intestinal syndrome. NOD/SCID mice received abdominal
irradiation at a selected dose of 5 Gy, and then infused intravenously with MnSOD-MSCs. Mice body weight, survival
and diarrhea were monitored for 30-days. Colonization and differentiation of MnSOD-MSCs in the irradiated intestine
were analyzed by histological and immunohistochemical methods. Consequently, our data demonstrated that intravenous
administration of MnSOD-MSCs improved survival, decreased diarrhea occurrence and protected the small intestinal
structural integrity of irradiated mice. Moreover, intravenously transplanted MnSOD-MSCs could colonize the irradiated
intestine and repair injured sites. These findings suggested that MnSOD-MSCs may be an attractive and potential option
for radiation-induced intestinal injury.
Keywords: Abdominal irradiation, mesenchymal stem cells, manganese superoxide dismutase, small intestinal injury.
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