Anti-Cancer Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Michelle Prudhomme  
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex


Phytochemical and Biological Activities of an Anticancer Plant Medicine: Brucea javanica

Author(s): Lijuan Zhao, Chao Li, Yao Zhang, Qing Wen and Dongmei Ren

Affiliation: Department of Natural Products Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, PR China.


In this review, the literature data on recent advances of the medicinal plant Brucea javanica (L.) Merr. (Simaroubaceae), both phytochemical and biological investigations, are compiled. Brucea javanica is an evergreen shrub distributed widely in Southeast Asia and northern Australia. In China, the seeds of Brucea javanica have been used as traditional herbal medicine due to its multifaceted activities. To date, 153 compounds have been reported from the seeds and aerial parts of Brucea javanica. Quassinoids are the main constituents of this species. The extract of Brucea javanica and the isolated compounds especially quassinoids exhibited various biological properties, such as antitumor and antimalarial effects.

Keywords: Brucea javanica, biological activities, chemical constituents, quassinoids

Order Reprints Order Eprints Rights & PermissionsPrintExport

Article Details

Page: [440 - 458]
Pages: 19
DOI: 10.2174/18715206113136660336