Abstract
Some kinds of amphiphilic lipids can spontaneously self-assemble with a proper ratio of water to form liquid crystalline, also known as cubic phase. With a curved bi-continuous lipid bilayer and two congruent networks of water channels, cubic phases can enclose hydrophilic, amphiphilic and hydrophobic drugs for delivery. Nanostructured cubosomes, prepared by fragmentation of bulk cubic phase gels or lyotropic methods, retain the same inner structure of cubic phase and possess much larger specific surface area and lower viscosity. These unique properties make cubosomes excellent delivery systems applicable for oral, mucosal, transdermal and parenteral drug delivery. This article gave an overview of the accelerated development and current status of cubosomes research, with respect to their preparation, characteristics and applications in pharmaceutics.
Keywords: cubosomes, cubic phase, liquid crystalline, nanostructure, drug delivery, preparation, characteristic, application.
Current Pharmaceutical Design
Title:Nanostructed Cubosomes as Advanced Drug Delivery System
Volume: 19 Issue: 35
Author(s): Xin Pan, Ke Han, Xinsheng Peng, Zhiwen Yang, Lingzhen Qin, Chune Zhu, Xintian Huang, Xuan Shi, Linghui Dian, Ming Lu and Chuanbin Wu
Affiliation:
Keywords: cubosomes, cubic phase, liquid crystalline, nanostructure, drug delivery, preparation, characteristic, application.
Abstract: Some kinds of amphiphilic lipids can spontaneously self-assemble with a proper ratio of water to form liquid crystalline, also known as cubic phase. With a curved bi-continuous lipid bilayer and two congruent networks of water channels, cubic phases can enclose hydrophilic, amphiphilic and hydrophobic drugs for delivery. Nanostructured cubosomes, prepared by fragmentation of bulk cubic phase gels or lyotropic methods, retain the same inner structure of cubic phase and possess much larger specific surface area and lower viscosity. These unique properties make cubosomes excellent delivery systems applicable for oral, mucosal, transdermal and parenteral drug delivery. This article gave an overview of the accelerated development and current status of cubosomes research, with respect to their preparation, characteristics and applications in pharmaceutics.
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Cite this article as:
Pan Xin, Han Ke, Peng Xinsheng, Yang Zhiwen, Qin Lingzhen, Zhu Chune, Huang Xintian, Shi Xuan, Dian Linghui, Lu Ming and Wu Chuanbin, Nanostructed Cubosomes as Advanced Drug Delivery System, Current Pharmaceutical Design 2013; 19 (35) . https://dx.doi.org/10.2174/1381612811319350006
DOI https://dx.doi.org/10.2174/1381612811319350006 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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