Abstract
Neuropathic pain is a serious consequence of injury or disease in the nervous system itself. Current treatment options for this condition are often unsatisfactory. From being originally viewed as a diseased caused by neuronal dysfunction, a growing body of evidence implicate activated microglia as a key player in the development of this pain condition. In this review, some of the evidence for this proposal is briefly discussed and placed in a translational context, pointing out the difficulties in translating commonly used animal models of neuropathic pain to the clinical condition, as well as emphasizing the broader role of activated microglia in the injured or diseased nervous system.
Keywords: Nerve injury, spinal cord injury, neuropathy, cytokine, chemokine, purine receptor, plasticity.
CNS & Neurological Disorders - Drug Targets
Title:Microglia and Neuropathic Pain
Volume: 12 Issue: 6
Author(s): Håkan Aldskogius and Elena N. Kozlova
Affiliation:
Keywords: Nerve injury, spinal cord injury, neuropathy, cytokine, chemokine, purine receptor, plasticity.
Abstract: Neuropathic pain is a serious consequence of injury or disease in the nervous system itself. Current treatment options for this condition are often unsatisfactory. From being originally viewed as a diseased caused by neuronal dysfunction, a growing body of evidence implicate activated microglia as a key player in the development of this pain condition. In this review, some of the evidence for this proposal is briefly discussed and placed in a translational context, pointing out the difficulties in translating commonly used animal models of neuropathic pain to the clinical condition, as well as emphasizing the broader role of activated microglia in the injured or diseased nervous system.
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Cite this article as:
Aldskogius Håkan and Kozlova N. Elena, Microglia and Neuropathic Pain, CNS & Neurological Disorders - Drug Targets 2013; 12 (6) . https://dx.doi.org/10.2174/18715273113126660168
DOI https://dx.doi.org/10.2174/18715273113126660168 |
Print ISSN 1871-5273 |
Publisher Name Bentham Science Publisher |
Online ISSN 1996-3181 |
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