Albendazole, an anthelmintic drug belonging to BCS class II, is having poor bioavailability which is dissolution rate dependent and hence needs novel approach for enhancement of bioavailability. The aim of the study was to develop nanosuspension of albendazole by different techniques like nanoprecipitation, emulsion template and sonication. Nanosuspensions were prepared using polyvinylpyrrolidone K30as a stabilizer and tween 80 as a surfactant. Prepared nanosuspensions were characterized for average particle size, zeta potential, particle size distribution, pH, viscosity, photomicrography, sedimentation, redispersibility and % drug content. In vitro release study were performed in 0.1N HCl using cellophane membrane and compared with marketed product. Residual solvent determination was carried out by gas chromatography for nanosuspensions prepared by nanoprecipitation and emulsion template techniques. All the results of characterization were satisfactory. The prepared nanosuspensions showed particle size of 673±9.18 nm to 893±21.6 nm, zeta potential of -8.70±0.5mV to -8.96±0.8, polydispersity index of 0.204±0.04 to 0.644±0.07. In vitro release study of the prepared nanosuspensions showed up to 33.80% to 42.92% drug release in first hour which higher than the marketed suspension which was showed only 16.19% release in first hour. The optimizednanosuspensions showed up to 97.05 % drug release within 6-8 hours while marketed product showed up to 91.03% drug release within 10 hours.
Albendazole, bioavailability, dissolution, emulsion template, nanoprecipitation, sonication
Department of Pharmaceutics, Maliba Pharmacy College, UkaTarsadia University, Gopalvidyanagar-394350, Gujarat, India.