Development of Albendazole Nanosuspension by Various Techniques
Akshay Koli, Himanshu Bhatt, Ashish Patel, Sandip Bhagat, Shailesh Shah and Ketan Ranch
Affiliation: Maliba Pharmacy College, Department of Pharmaceutics, Uka Tarsadia University, Gopalvidyanagar- 394350, Dist. Surat, Gujarat, India.
Albendazole, an anthelmintic drug belonging to BCS class II, has poor bioavailability. Bioavailability is dissolution
rate dependent and hence needs novel approach for enhancement of bioavailability. The aim of the study was to develop
nanosuspension of albendazole by using various techniques like nanoprecipitation, emulsion template and sonication.
Nanosuspensions were prepared using polyvinylpyrrolidone K30 as a stabilizer and Tween 80 as a surfactant. Average
particle size, zeta potential, particle size distribution, pH, viscosity, photomicrography, sedimentation, redispersibility
and % drug content were determined to characterize prepared nanosuspensions. In vitro release study was performed in
0.1N HCl using cellophane membrane and compared with marketed product. Residual solvent determination was carried
out by gas chromatography for nanosuspensions prepared by nanoprecipitation and emulsion template techniques. All the
results obtained for characterization were satisfactory. The prepared nanosuspensions showed particle size 673±9.18 nm
to 893±21.6 nm, zeta potential -8.70±0.5mV to -8.96±0.8, polydispersity index 0.204±0.04 to 0.644±0.07. In vitro release
study of the nanosuspensions showed 33.80% to 42.92% drug release in first hour which was higher than the marketed
suspension (16.19% release in first hour). The optimized nanosuspensions showed up to 97.05 % drug release within 6-8
hours while marketed product showed up to 91.03% drug release within 10 hours.
Keywords: Albendazole, bioavailability, dissolution, emulsion template, nanoprecipitation, sonication.
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