Genomic Linkage Between Alzheimer's Disease and Type 2 Diabetes
Taoufik Nedjadi, Absarul Haque, Qamre Alam, Siew H. Gan, Adeel G. Chaudhary, Adel M. Abuzenadah, Ghazi A. Damanhouri and Mohammad A. Kamal
Affiliation: Fundamental and Applied Biology Group, King Fahd Medical Research Centre, King Abdulaziz University, P. O. Box 80216, Jeddah 21589, Saudi Arabia.
Alzheimer’s disease (AD) is a major health concern that affects nearly every society worldwide. The disease is
an irreversible, progressive and age-related neurodegenerative disorder. It is characterized by impaired cognitive function
and the diffuse deposition of amyloid plaques and neurofibrillary tangles. The causes of AD and the underlying
mechanisms that trigger the onset of the disease are still a matter of debate. Several epidemiological studies have shown
that the development of AD is associated with type 2 diabetes mellitus (T2D). In this review, we provide evidence for the
link between T2D and AD, highlighting the critical role of insulin in the pathogenesis of these diseases, and we provide
information on the genes that might be involved in the interplay between these two disorders. New insight into the
complex biology of AD is necessary for the early diagnosis of the disease, the development of novel drug therapies and
the prevention of these health issues.
Keywords: Alzheimer’s disease, type-2 diabetes, insulin, insulin resistance, genes.
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