Insulin-Degrading Enzyme: A Link Between Alzheimer’s and Type 2 Diabetes Mellitus

Author(s): Rizwanul Haque, Aamir Nazir.

Journal Name: CNS & Neurological Disorders - Drug Targets

Volume 13 , Issue 2 , 2014

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Abstract:

Enzymes play a very vital role in maintaining the homeostasis inside the body. Improper functioning of enzymes is associated with many diseases. Insulin-degrading enzyme (IDE), a ubiquitously expressed zinc metalloprotease, is believed to act as a junction point of Type 2 Diabetes and Alzheimer’s disease. Recent studies provide inkling for the use of IDE as a potential target hence the design of its regulators would be a viable approach towards treatment of these diseases. This review provides an overview of the IDE structure and function; a relationship is drawn between IDE, Type 2 Diabetes mellitus and Alzheimer’s disease and the approaches that make IDE a potential target, are discussed.

Keywords: Insulin degrading enzyme, Alzheimer’s disease, Type 2 Diabetes mellitus, Caenorhabditis elegans.

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Article Details

VOLUME: 13
ISSUE: 2
Year: 2014
Page: [259 - 264]
Pages: 6
DOI: 10.2174/18715273113126660139
Price: $58

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