Fighting Alzheimer's Disease and Type 2 Diabetes: Pathological links and Treatment Strategies
Ying Dai and Mohammad A. Kamal
Pages 271-282 (12)
The incidence of Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM) with associated serious
complications continues to grow rapidly especially in developed countries. Emerging evidence indicates that AD and
T2DM share some common risk factors with comparable pathological features including insulin resistance,
amyloidogenesis, glucocorticoid imbalance, inflammation, mitochondrial function and oxidative stress. T2DM has been
identified as a risk factor for AD. It has even been hypothesized that AD might be “type 3 diabetes”. In addition to
amyloid precursor protein processing and tau phosphorylation, commonalities between T2DM and AD in molecular
mechanisms provide clues to the identification of novel therapeutic targets such as glucagon-like peptide 1,
butyrylcholinesterase, and receptor for advanced glycosylation end products. Although several classes of anti-diabetic
drugs are available, achieving long-term glycaemic control without side effects is often challenging. This review
summarizes recent evidence for the pathological links, common therapeutic targets, currently the U.S. Food and Drug
Administration approved and potential future therapies, giving special attention to ongoing clinical trials of antidiabetic
drugs in AD patients and common therapeutic strategies in the management of both AD and T2DM.
Alzheimer's disease, clinical trial, dementia, diabetes, insulin, pathogenic mechanism, therapeutic targets.
Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Room CLS- 628, Brookline, MA 02445, USA.