Synthesis and In Vitro Anticancer Activity of Novel 2-((3-thioureido)carbonyl) phenyl Acetate Derivatives

Title:Synthesis and In Vitro Anticancer Activity of Novel 2-((3-thioureido)carbonyl) phenyl Acetate Derivatives

Volume: 11 Issue: 2

Author(s): Lin Xiong, Ya-Qin Gao, Chu-E Niu, Hong-Bo Wang and Wei-Hong Li

Affiliation:

Keywords: Anticancer activity, Aspirin derivatives, Anti-leukemia activity, Synthesis, MTT, In vitro.

Abstract: Novel simplified Aspirin derivatives were developed, characterized by using IR, ¹H NMR, ¹³C NMR and elemental analysis techniques and evaluated for anticancer activity in human cell lines. The results revealed that most of the compounds exhibited inhibitory effects of growth of cancer cell lines in vitro against T-acute lymphoblastic leukemia cell lines Molt-4, chronic myclogenous leukemia cell lines K-562, acute myelocytic leukemia cells lines HL-60, human breast cancer cell lines MCF-7, human hepatic carcinoma cell lines HepG-2 and human lung cancer cell lines A-549. It was observed that some of these compounds exhibited significant anticancer activity particularly 5i which had stronger antileukemia activity with IC₅₀ values ranging from 11.12 to 19.25 µmol·L-1 against 3 leukemia cells than control fluorouracil, so some of the compounds may constitute a novel class of anticancer medicines, which deserves further study.

Cite this article as:

Xiong Lin, Gao Ya-Qin, Niu Chu-E, Wang Hong-Bo and Li Wei-Hong, Synthesis and In Vitro Anticancer Activity of Novel 2-((3-thioureido)carbonyl) phenyl Acetate Derivatives, Letters in Drug Design & Discovery 2014; 11 (2) . https://dx.doi.org/10.2174/15701808113106660075