Synthesis and In Vitro Anticancer Activity of Novel 2-((3-thioureido)carbonyl) phenyl Acetate Derivatives
Lin Xiong, Ya-Qin Gao, Chu-E Niu, Hong-Bo Wang and Wei-Hong Li
Affiliation: Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730050, China.
Novel simplified Aspirin derivatives were developed, characterized by using IR, 1H NMR, 13C NMR and elemental
analysis techniques and evaluated for anticancer activity in human cell lines. The results revealed that most of the
compounds exhibited inhibitory effects of growth of cancer cell lines in vitro against T-acute lymphoblastic leukemia cell
lines Molt-4, chronic myclogenous leukemia cell lines K-562, acute myelocytic leukemia cells lines HL-60, human breast
cancer cell lines MCF-7, human hepatic carcinoma cell lines HepG-2 and human lung cancer cell lines A-549. It was observed
that some of these compounds exhibited significant anticancer activity particularly 5i which had stronger antileukemia
activity with IC50 values ranging from 11.12 to 19.25 µmol·L-1 against 3 leukemia cells than control fluorouracil,
so some of the compounds may constitute a novel class of anticancer medicines, which deserves further study.
Keywords: Anticancer activity, Aspirin derivatives, Anti-leukemia activity, Synthesis, MTT, In vitro.
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