The search for novel lead from the group of various substituted N-piperazine ether derivatives was performed.
Acyl- and pyridylpiperazine ethyl/propyl ethers were obtained via three different synthetic pathways. Affinity to
histamine H3 receptor was established, as well as, for selected compounds, selectivity towards histamine H4R. Docking
studies to the histamine H3R homology model strengthened the position of (4-(3-(4-(3-chlorobenzoyl)piperazin-1-
yl)propoxy)phenyl)(cyclopropyl)methanone (compound 26) as a novel lead for further studies on histamine H3 receptor
Keywords: Acylpiperazine, histamine H3R affinity, histamine H4R affinity, molecular docking, non-imidazole histamine H3R
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