Design, Synthesis and Cytotoxic Activity Evaluation of New Aminosubstituted Benzofurans

Author(s): Konstantinos Daniilides, Nikolaos Lougiakis, Nicole Pouli, Panagiotis Marakos, Pinelopi Samara, Ourania Tsitsilonis.

Journal Name: Medicinal Chemistry

Volume 10 , Issue 6 , 2014

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Abstract:

A number of new aminosubstituted benzofuran analogues have been prepared and their cytotoxic/cytostatic activity was investigated against five human tumor cell lines (MCF-7, SKBR3, SKOV3, HCT-116 and HeLa). Certain compounds showed noticeable tumor cell growth inhibition, indicative of possible structure-activity relationships.

Keywords: Benzofurans, Cytotoxicity, Heterocycles, Sonogashira cross-coupling, Wadsworth-Emmons reaction.

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Article Details

VOLUME: 10
ISSUE: 6
Year: 2014
Page: [619 - 627]
Pages: 9
DOI: 10.2174/15734064113096660049
Price: $58

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