Natural Products, Synthetic and Non-Nucleoside Compounds as Inhibitors of Enzymes Related to DNA: Update 2013
Carlos R. Pungitore
Affiliation: INTEQUI-CONICET, Facultad de Química Bioquímicay Farmacia, Universidad Nacional de San Luis, Chacabuco y Pedernera, 5700-San Luis, Argentina.
Keywords: DNA polymerases, inhibitors, natural products, non-nucleoside, reverse transcriptase, topoisomerases.
This review article tries to be an update of 2008 Pungitore’s review. Again, this paper tries to summarize the
investigation about natural products, synthetic and non-nucleoside compounds with the ability to inhibit enzymes that play
a crucial role in DNA metabolism such as replication, transcription, retro-transcription, recombination, and chromosome
segregation during mitosis. The focus is placed on DNA polymerases, topoisomerases and reverse transcriptase inhibitors
because most of the literature emphasized on their inhibitory activity. A great diversity of chemical compounds encompassing
triterpenes, flavonoids, chromones, lipids, iridoids, phytosterols, coumarins, anthracyclines, quinones, protoberberines,
tannins, lignans, acetogenins, benzimidazoles and other natural products, produced by different species of organisms,
have inhibitory activities against enzymes related to DNA metabolism allowing these enzymes to arise as important
molecular targets for cancer and AIDS research.
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