Synthesis and characterization of some novel phosphonate derivatives as uPA inhibitors have been conducted. HOMO and
LUMO energies, NPA charges, electrophilicity index and vibrational frequencies were calculated for the current and previously reported
phosphonates. Based on the calculated properties, the results obtained indicate that the novel compounds are expected to be more potent
than other phosphonates.
Keywords: DFT, electrophilicity, phosphonates synthesis, uPA inhibitors, SAR.
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