An Ion Channel Chip for Diagnosis and Prognosis of Autoimmune Neurological Disorders
Franck C. Chatelain, Michel Mazzuca, Marie-Madeleine Larroque, Veronique Rogemond, Jerome Honnorat and Florian Lesage
Affiliation: PMC CNRS, 660 Route des Lucioles, 06560 Valbonne Sophia Antipolis, France.
Keywords: Autoimmunity, excitability, ion channels, ionotropic receptors, protein array.
Autoantibodies directed against ion channels and ionotropic receptors are associated with neuromuscular and
neurological disorders. Their detection has proven to be useful for diagnosis, prognosis and treatment of these
autoimmune syndromes. We have designed an ion channel chip for the systematic and rapid screening of antibodies
directed against tens of different ion channels. The chip has been validated by confirming the presence of autoantibodies
in patients with anti-NMDA receptor encephalitis. Such a chip will be useful for the diagnosis of already documented
disorders, but also to identify new targets of autoimmunity and classification of the corresponding diseases. The article
presents some promising patents on the Ion Channel Chip.
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