Current Medicinal Chemistry

Atta-ur-Rahman, FRS
Honorary Life Fellow
Kings College
University of Cambridge


Alzheimer´s Disease and Oxidative Stress: A Review

Author(s): Miroslav Pohanka

Affiliation: Faculty of Military Health Sciences, University of Defence, Trebesska 1575, 50001 Hradec Kralove, Czech Republic.


Alzheimer´s disease (AD) is a neurodegenerative disorder with no known cure and rapid rise in incidence. The predominant cognitive impairment is currently treated using cognitive enhancers like cholinesterase inhibitors. The two molecular hallmarks of AD are amyloid plaques created from an amyloid precursor protein and hyperphosphorylated tau protein that is deposited as neurofibrillary tangles inside neurons. A number of pathological mechanisms follow or precede these formations. Alteration in mitochondrial function and deposition of heavy metals are reported. The disease progression is enhanced by oxidative stress. However, the role of oxidative stress is not universally accepted. The current review covers and discusses the basic evidence and role of oxidative stress in AD development.

Keywords: Alzheimer disease, amyloid plaque, tau, antioxidants, Fenton reaction, heavy metals, mitochondria, parkinson´s disease, reactive oxygen species.

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Article Details

Page: [356 - 364]
Pages: 9
DOI: 10.2174/09298673113206660258