This review describes several aspects required for the development of small molecule PET-tracers. Design and selection criteria
are important to consider before starting to develop novel PET-tracers. Principles and latest trends in 11C and 18F-radiochemistry are
summarized. In addition an update of some new developments in regulatory aspects is supplied.
Keywords: PET, small molecules, radiochemistry, preclinical evaluation, carbon-11, fluorine-18.
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