Current Pharmaceutical Design

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Small Molecule PET-Radiopharmaceuticals

Author(s): Philip H. Elsinga and Rudi A.J.O. Dierckx

Affiliation: University Medical Center Groningen, University of Groningen, the Netherlands and Ghent University, Belgium.

Keywords: PET, small molecules, radiochemistry, preclinical evaluation, carbon-11, fluorine-18.

Abstract:

This review describes several aspects required for the development of small molecule PET-tracers. Design and selection criteria are important to consider before starting to develop novel PET-tracers. Principles and latest trends in 11C and 18F-radiochemistry are summarized. In addition an update of some new developments in regulatory aspects is supplied.

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Article Details

VOLUME: 20
ISSUE: 14
Page: [2268 - 2274]
Pages: 7
DOI: 10.2174/13816128113196660661