Current HIV Research

Charles Wood  
University of Nebraska
Lincoln, NE


Recent Advances on the Use of Structural Biology for the Design of Novel Envelope Immunogens of HIV-1

Author(s): Shi-Hua Xiang

Affiliation: Nebraska Center for Virology, School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Morrison Center 143, 4240 Fair Street, Lincoln, NE 68583-0900, USA.


Many efforts have been made in the worldwide quest for a prophylactic HIV vaccine to end the AIDS pandemic, but none has yet succeeded. The lessons learned have repeatedly informed us that the traditional or conventional approaches directly using the pathogens or subunits will not be sufficient for an effective HIV/AIDS vaccine. Recent advances in structure-based technology have shown some promise in the quest for a better immunogen in HIV vaccine development. According to the basic binding structural relationship of an antigen and an antibody, structurebased antigen design could bring some hope for the development of an effective vaccine against HIV.

Keywords: Antibody epitope, envelope trimer, germline B-cells, HIV-1, immunogen design, structure-based design, vaccine development.

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Article Details

Page: [464 - 472]
Pages: 9
DOI: 10.2174/1570162X113116660053