The Inflammatory Bowel Disease (IBD) comprises two forms Ulcerative Colitis (UC) and Crohn's Disease (CD). The intestinal inflammation in IBD is controlled by a complex interplay of innate and adaptive immune mechanisms. Evidence indicates that a dysregulation of these mechanisms in the mucosal immunity of the gut in IBD patients causes an overproduction of cytokines leading to an uncontrolled intestinal inflammation. The discovery of novel cytokines in the IBD is important in order to understand the mechanisms that are involved in the gut mucosal immunity, as well as the design of new therapeutic targets focused on the production of specific cytokine inhibitors.
Head of IBD Clinic, Department of Gastroenterology Instituto Nacional de Ciencias Médicas y Nutrición Vasco de Quiroga #15. Col. Sección XVI, Tlalpan, CP 14000 México.