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Letters in Organic Chemistry
ISSN (Print): 1570-1786
ISSN (Online): 1875-6255
Epub Full Text Article
DOI: 10.2174/157017861131000061      Price:  $95









HClO4-SiO2 as an efficient and reusable heterogeneous catalyst for the synthesis of 1-substituted tetrazoles

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Author(s): Siavash Bahari and Akbar Rezaei
Abstract:
An efficient and direct protocol is described for the preparation of 1-substituted 1H-1,2,3,4-tetrazoles by the reaction of primary amines, triethyl orthoformate and sodium azide in the presence of catalytic amount of silica-supported perchloric acid under solvent-free and heterogeneous conditions. The thermal solvent-free green procedure offers advantages such as simple methodology, easy work-up, high yield, recovery and reusability of catalyst.
Keywords:
Primary amines, triethyl orthoformate, 1-substituted 1H-1, 2, 3, 4-tetrazole, HCl4-SiO2, heterogeneous catalyst.
Affiliation:
Department of Chemistry, Ahar Branch, Islamic Azad University, Ahar, Iran.