A high efficient and environmentally friendly procedure for the production of bis thiazolidinones has been developed.
This synthetic approach involves the simple condensation of an appropriate dialdehyde and N,N'-diarylthioureas
with chloroacetyl chloride in eutectic salts as a promoter and solvent at 80 °C. All products were obtained in good to excellent
yields. Structures of these compounds were established on the basis of IR, 1H-NMR, 13C-NMR and by elemental
Keywords: Bis thiazolidinone heterocycles, choline chloride, green chemistry, ionic liquids, multicomponent reactions,
Rights & PermissionsPrintExport