Medicinal Chemistry

Atta-ur-Rahman  
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK
Email: mc@benthamscience.org

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Defense Mechanisms of the Respiratory System and Aerosol Production Systems

Author(s): Paul Zarogoulidis, Kaid Darwiche, Lonny Yarmus, Dionysios Spyratos, Nevena Secen, Wolfgang Hohenforst-Schmidt, Nikolaos Katsikogiannis, Haidong Huang, Andreas Gschwendtner and Konstantinos Zarogoulidis

Affiliation: Pulmonary Department, “G. Papanikolaou” General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Keywords: Respiratory system, defense mechanisms, aerosol, dry powder, inhalers.

Abstract:

Aerosolized therapies have been used in everyday clinical practice for decades. Experimentation with different delivery systems have led to the creation of aerosolized insulin, antibiotics, gene therapy and chemotherapy. Several of these therapies are already clinically available while others are being investigated in active clinical trials. The main factors affecting the efficiency and safety of the aerosolized therapies are the production of the aerosol, distribution/deposition of the aerosol throughout the lung parenchyma, respiratory defense mechanisms and tissue/pharmaceutical molecule interactions. Current methods of aerosol production and distribution will be presented along with an overview of the respiratory defense mechanisms. In addition, methods of aerosol evaluation in conjunction with a future perspective of the potential development of aerosol therapies will be presented.

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Article Details

VOLUME: 10
ISSUE: 2
Page: [123 - 136]
Pages: 14
DOI: 10.2174/157340641130900041