Anti-Cancer Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Michelle Prudhomme  
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France

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Genetics, Structure, Function, Mode of Actions and Role in Cancer Development of CYP17

Author(s): Tatyana. A Sushko, Andrei A. Gilep, Sergey A. Usanov.

Abstract:

Most prostate and breast cancers are hormone dependent. The inhibition of steroid 17α-hydroxylase/17,20- lyase (CYP17), which is a crucial enzyme for steroid hormone biosynthesis, is widely used to treat androgen-dependent prostate cancer (PC). CYP17 has dual enzymatic activity: 17alpha-hydroxylase activity (utilizing delta4- C21 steroids as substrates) and the 17,20-lyase activity (using delta5- C21 steroids as substrates). The steroid biosynthetic pathway is directed to either the production of corticosteroids or sex hormones depending on the activity of CYP17. In this review, the current information on the genetics, molecular structure, substrate specificity and inhibitors of CYP17 is analyzed and discussed.

Keywords: Cytochrome P450, CYP17, hormone-dependent cancer, inhibitors of androgen biosynthesis, prostate cancer, steroid hormone biosynthesis, steroid 17α-hydroxylase, 17, 20-lyase.

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Article Details

VOLUME: 14
ISSUE: 1
Year: 2014
Page: [66 - 76]
Pages: 11
DOI: 10.2174/187152061131300330