Pharmacokinetics of CNT-based Drug Delivery Systems

Author(s): Rui Ye, Sheng Wang, Jing Wang, Zhiqiang Luo, Qiang Peng, Xiaoxiao Cai, Yunfeng Lin.

Journal Name: Current Drug Metabolism

Volume 14 , Issue 8 , 2013

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Abstract:

Carbon nanotubes (CNT) are allotropes of carbon with a cylindrical nanostructure. They have recently aroused great interests as drug carriers, but their pharmacokinetic profiles which determine their potentials in clinical application are yet to be fully understood. Therefore, this overview attempts to outline the processes of absorption, distribution, metabolism and excretion (ADME) that govern the pharmacokinetics of CNT. In addition, the molecular mechanisms of intracellular internalization and drug release are also discussed.

Keywords: Absorption, CNT, distribution, drug release, excretion, intracellular internalization, metabolism, tumor targeting.

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Article Details

VOLUME: 14
ISSUE: 8
Year: 2013
Page: [910 - 920]
Pages: 11
DOI: 10.2174/138920021131400113
Price: $58

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