Focus on Microwaves Assisted Halogen-halogen Exchange Reaction Conditions on 2-Halopyridines
Marcella De Giorgi,
Anne Sophie Voisin-Chiret.
This paper describes an optimised microwave irradiation methodology on various substituted pyridines in order
to realise a halogen-halogen exchange. This protocol provides an efficient and simple methodology to improve the reactivity
of some positions on the pyridine ring towards metallocatalysed reactions. Influence of various substituents has been
explored and limiting factors of reaction have been highlighted.
Keywords: Acetyl chloride, 2, 3-dihalopyridine, 2, 4-dihalopyridine, 2, 6-diahlopyridine, 2-halopyridine, halogen exchange,
regioselectivity, microwaves, sodium iodide, suzuki-Miyaura cross-coupling reaction.
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