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Mini-Reviews in Medicinal Chemistry
ISSN (Print): 1389-5575
ISSN (Online): 1875-5607
VOLUME: 14
ISSUE: 3
DOI: 10.2174/13895575113139990081      Price:  $58









Recent Development in [1,4]Benzodiazepines as Potent Anticancer Agents: A Review

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Author(s): Rupinder Kaur Gill, Shiv Om Kaushik, Jasreen Chugh, Sumit Bansal, Anamik Shah and Jitender Bariwal
Pages 229-256 (28)
Abstract:
The [1,4]benzodiazepine is an important class of heterocyclic compounds and clinically used for many ailments in humans. The [1,4]benzodiazepine has unique structure that mimics the peptide linkage. This interesting observation completely shifted the interest of medicinal chemist for [1,4]benzodiazepine from CNS acting drugs to anticancer agents. During last few decades, a large number of reports have appeared in the literature highlighting the anticancer activity of [1,4]benzodiazepines. Here, in this article, we have discussed the brief synthesis, origin of [1,4]benzodiazepines as anticancer agent, their mechanism of action and latest developments in this field. We have compiled the most important literature reports from last few decades till date.
Keywords:
Anticancer, [1, 4]Benzodiazepines, DNA intercalating agents, Pyrrolo[1, 4]benzodiazepine, Antiarrhythmic agents, 2-Azidobenzoylchloride, Histone deacetylase inhibitors, Columbic interactions.
Affiliation:
Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Moga-142001, Punjab, India.