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Recent Development in [1,4]Benzodiazepines as Potent Anticancer Agents: A Review

Author(s): Rupinder Kaur Gill, Shiv Om Kaushik, Jasreen Chugh, Sumit Bansal, Anamik Shah and Jitender Bariwal

Affiliation: Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Moga-142001, Punjab, India.

Keywords: Anticancer, [1, 4]Benzodiazepines, DNA intercalating agents, Pyrrolo[1, 4]benzodiazepine, Antiarrhythmic agents, 2-Azidobenzoylchloride, Histone deacetylase inhibitors, Columbic interactions.

Abstract:

The [1,4]benzodiazepine is an important class of heterocyclic compounds and clinically used for many ailments in humans. The [1,4]benzodiazepine has unique structure that mimics the peptide linkage. This interesting observation completely shifted the interest of medicinal chemist for [1,4]benzodiazepine from CNS acting drugs to anticancer agents. During last few decades, a large number of reports have appeared in the literature highlighting the anticancer activity of [1,4]benzodiazepines. Here, in this article, we have discussed the brief synthesis, origin of [1,4]benzodiazepines as anticancer agent, their mechanism of action and latest developments in this field. We have compiled the most important literature reports from last few decades till date.

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Article Details

VOLUME: 14
ISSUE: 3
Page: [229 - 256]
Pages: 28
DOI: 10.2174/13895575113139990081