Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Molecular Modeling and Ligand-Protein Interaction of N-Protein of Chandipura Virus

Author(s): Ganesh Chandra Sahoo, Md. Yousuf Ansari, Sindhuprava Rana, Manas Ranjan Dikhit, Roshan Kamal Topno, Krishna Pandey, Pradeep Das.

Abstract:

In different RNA viruses, the nucleocapsid protein N (N protein) plays an important functional role by enwrapping the viral genomic RNA in an RNase-resistant form. Targeting this essential protein is one of the best methods to find novel Chandipura virus (CHPV) inhibitors. The model of N protein of CHPV showed that this protein bears an alpha helical type topology. Computational characterization of N protein of CHPV exhibited that it bears DNA/ RNA binding region. Among all of the computationally screened compounds by GOLD, Flex X and ligandfit (DSv2.5) programs, antiviral compounds such as nelfinavir, acyclovir, azidothymidine are having very high binding affinity towards N protein of CHPV.

Keywords: Nucleocapsid protein N, Chandipura Virus, AES, Acyclovir, Alpha helical type topology, Dock score.

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Article Details

VOLUME: 11
ISSUE: 2
Year: 2014
Page: [211 - 221]
Pages: 11
DOI: 10.2174/15701808113109990070
Price: $58