Molecular Modeling and Ligand-Protein Interaction of N-Protein of Chandipura Virus
Ganesh Chandra Sahoo,
Md. Yousuf Ansari,
Manas Ranjan Dikhit,
Roshan Kamal Topno,
In different RNA viruses, the nucleocapsid protein N (N protein) plays an important functional role by enwrapping
the viral genomic RNA in an RNase-resistant form. Targeting this essential protein is one of the best methods to find novel
Chandipura virus (CHPV) inhibitors. The model of N protein of CHPV showed that this protein bears an alpha helical type
topology. Computational characterization of N protein of CHPV exhibited that it bears DNA/ RNA binding region. Among
all of the computationally screened compounds by GOLD, Flex X and ligandfit (DSv2.5) programs, antiviral compounds
such as nelfinavir, acyclovir, azidothymidine are having very high binding affinity towards N protein of CHPV.
Keywords: Nucleocapsid protein N, Chandipura Virus, AES, Acyclovir, Alpha helical type topology, Dock score.
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