Abstract
The present research work was aimed to design the transdermal delivery system of naproxen using Aloe vera as aqueous gel base. Aloe vera would able to potentiate the anti-inflammatory effect and also act as penetration enhancer. Carbopol 934 was used as a gelling agent. The prepared gel was assessed for pH, permeation parameters, drug content, skin irritation and in-vitro diffusion. Accelerated stability study was also carried out. In-vivo studies were performed to characterize the efficacy of the prepared naproxen-Aloe vera transgel (NAG). The pH of formulation was found to be 6.98. The values of permeation data for flux, permeability coefficient and enhancement ratio were obtained as 0.00907 µg cm-2 h-1, 0.00453 cm h-1 and 5.96 respectively. The viscosity was found as 610 cps for NAG. The drug release kinetics followed Higuchi model. Stability study has proved the integrity of the formulation. No skin irritation was observed in Wistar albino rats. Anti-inflammatory assessment in Wistar rats showed significant effect in paw-volume reduction at p<0.05 in less than one hour for NAG compared to that of plain Aloe gel and commercial naproxen gel (CNG). The prepared naproxen-Aloe gel (NAG) could able to show better anti-inflammatory activity compared to the CNG. This could be attributed by synergistic effect of Aloe.
Keywords: Diffusion, flux, paw edema, percent inhibition, permeability enhancement.
Drug Delivery Letters
Title:Pharmaceutical and Pharmacodynamic Evaluation of Naproxen Incorporated Aloe vera Transgel
Volume: 4 Issue: 2
Author(s): Thushara B. Dudala, Prasanna R. Yalavarthi, Rao P. Satyanarayana, Haritha Kodavatikanti, K.R. Vandana, Vinesha Velam and Harini C. Vadlamudi
Affiliation:
Keywords: Diffusion, flux, paw edema, percent inhibition, permeability enhancement.
Abstract: The present research work was aimed to design the transdermal delivery system of naproxen using Aloe vera as aqueous gel base. Aloe vera would able to potentiate the anti-inflammatory effect and also act as penetration enhancer. Carbopol 934 was used as a gelling agent. The prepared gel was assessed for pH, permeation parameters, drug content, skin irritation and in-vitro diffusion. Accelerated stability study was also carried out. In-vivo studies were performed to characterize the efficacy of the prepared naproxen-Aloe vera transgel (NAG). The pH of formulation was found to be 6.98. The values of permeation data for flux, permeability coefficient and enhancement ratio were obtained as 0.00907 µg cm-2 h-1, 0.00453 cm h-1 and 5.96 respectively. The viscosity was found as 610 cps for NAG. The drug release kinetics followed Higuchi model. Stability study has proved the integrity of the formulation. No skin irritation was observed in Wistar albino rats. Anti-inflammatory assessment in Wistar rats showed significant effect in paw-volume reduction at p<0.05 in less than one hour for NAG compared to that of plain Aloe gel and commercial naproxen gel (CNG). The prepared naproxen-Aloe gel (NAG) could able to show better anti-inflammatory activity compared to the CNG. This could be attributed by synergistic effect of Aloe.
Export Options
About this article
Cite this article as:
B. Dudala Thushara, R. Yalavarthi Prasanna, P. Satyanarayana Rao, Kodavatikanti Haritha, Vandana K.R., Velam Vinesha and C. Vadlamudi Harini, Pharmaceutical and Pharmacodynamic Evaluation of Naproxen Incorporated Aloe vera Transgel, Drug Delivery Letters 2014; 4 (2) . https://dx.doi.org/10.2174/22103031113039990012
DOI https://dx.doi.org/10.2174/22103031113039990012 |
Print ISSN 2210-3031 |
Publisher Name Bentham Science Publisher |
Online ISSN 2210-304X |
Call for Papers in Thematic Issues
Nanomaterial Assisted Targeted Therapies for Chronic Disorders- Preclinical to Clinical Outcomes
In recent years, the integration of nanomaterials into therapeutic strategies has emerged as a promising avenue in the pursuit of more effective treatments for chronic disorders. This dynamic field, explored in the context of "Nanomaterial Assisted Targeted Therapies for Chronic Disorders - Preclinical to Clinical Outcomes," seeks to bridge the ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Fetal Mesenchymal Stem Cells in Cancer Therapy
Current Stem Cell Research & Therapy The use of nanocarriers in acute myeloid leukaemia therapy: challenges and current status.
Current Pharmaceutical Biotechnology Survey of Recent Literature Related to the Biologically Active 4(3H)-Quinazolinones Containing Fused Heterocycles
Current Medicinal Chemistry Cinnamic Acid Derivatives in Tuberculosis, Malaria and Cardiovascular Diseases - A Review
Current Organic Chemistry Signaling Pathways Responsible for Cancer Cell Invasion as Targets for Cancer Therapy
Current Cancer Drug Targets Radiolabelled Probes Targeting Tumor Hypoxia for Personalized Medicine
Current Pharmaceutical Design Review of the Biological Activity of Maslinic Acid
Current Drug Targets Discovery of Small Molecule c-Met Inhibitors: Evolution and Profiles of Clinical Candidates
Anti-Cancer Agents in Medicinal Chemistry Multidisciplinary Treatment of Early Stage Endometrial Cancer
Anti-Cancer Agents in Medicinal Chemistry Ultrasound Imaging of Cervical Anatomic Variants
Current Medical Imaging Extracellular Vesicles in the Treatment of Parkinson’s Disease: A Review
Current Medicinal Chemistry Recent Advances on the Development of Pharmacotherapeutic Agents on the Basis of Human Serum Albumin
Current Pharmaceutical Design Recent Advances in Semisynthesis, Biosynthesis, Biological Activities,Mode of Action, and Structure-Activity Relationship of Podophyllotoxins:An Update (2008-2010)
Mini-Reviews in Medicinal Chemistry Bortezomib Enhances the Antitumor Effects of Interferon-β Gene Transfer on Melanoma Cells
Anti-Cancer Agents in Medicinal Chemistry Role of Inflammation-Associated Microenvironment in Tumorigenesis and Metastasis
Current Cancer Drug Targets Calcium Antagonists: A Ready Prescription for Treating Infectious Diseases?
Current Topics in Medicinal Chemistry BRAF Inhibitor Therapy for Melanoma, Thyroid and Colorectal Cancers: Development of Resistance and Future Prospects
Current Cancer Drug Targets Transforming Growth Factor-β: A Molecular Target for the Future Therapy of Glioblastoma
Current Pharmaceutical Design Targeted Theranostics Against Solid Cancer Using Metal Bond Milk Protein and Aptamers
Current Topics in Medicinal Chemistry Novel Concepts in the Development of Platinum Antitumor Drugs
Current Medicinal Chemistry - Anti-Cancer Agents