Ibuprofen is one of the most popular NSAIDs for the last three decades but also known for its gastrointestinal
side effects similar to other NSAIDs. To overcome this problem, we have designed and synthesized ibuprofen - antioxidant
(thymol, guaiacol, eugenol, and menthol) hybrids (6-13) with and without spacer as gastro sparing agents. The hybrids
have been found to be chemically stable, biolabile and exhibited retention of anti-inflammatory and analgesic activity
with significant reduced ulcerogenicity as compared to the ibuprofen and ibuprofen + antioxidant physical mixture.
The absence of ulcerogenicity may be attributed to antioxidants and improved physicochemical properties of these hybrid
Keywords: Ibuprofen, Antioxidants, Ulcerogenicity, Chemical stability.
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