The results of numerous clinical trials with statins and other drugs have demonstrated the principal possibility of the prevention
and regression of atherosclerosis by pharmacotherapy. This review describes the use of cultured human arterial cells for the mass
screening of anti-atherosclerotic substances, the investigation of the mechanisms responsible for their atherosclerosis-related effects, and
the optimization of anti-atherosclerotic and anti-atherogenic drug and dietary therapies. Natural products can be considered promising
drugs for anti-atherosclerotic therapy. Our basic studies have shown that cellular lipidosis is the principal event in the genesis of atherosclerotic
lesions. Using cellular models and natural products, we have developed an approach to prevent lipid accumulation in arterial
cells. Based on our knowledge of atherosclerosis, we developed drugs that possess direct anti-atherosclerotic activity. Two-year treatment
with allicor (garlic powder) has a direct anti-atherosclerotic effect on carotid atherosclerosis in asymptomatic men. Inflaminat (calendula,
elder, and violet), which possesses anti-cytokine activity, has been shown to cause the regression of carotid atherosclerosis following the
treatment of asymptomatic men for one year. The phytoestrogen-rich drug karinat (garlic powder, extract of grape seeds, green tea leaves,
hop cones, β-carotene, α-tocopherol, and ascorbic acid) prevents the development of carotid atherosclerosis in postmenopausal women.
Thus, our basic findings were successfully translated into clinical practice. Because of this translation, a novel approach to antiatherosclerotic
therapy was developed. Our clinical trial confirmed the efficacy of both the novel approach and the novel drugs.