Cyclophilins in Atherosclerosis: A New Therapeutic Target?

Author(s): Michael Bukrinsky , Alexander Orekhov , Michael Ditiatkovski , Dmitri Sviridov .

Journal Name: Current Pharmaceutical Design

Volume 19 , Issue 33 , 2013

Abstract:

Atherosclerosis is a chronic disease with a significant inflammatory component. Recent studies indicate a role of extracellular cyclophilins as contributors to endothelial inflammation and pathogenesis of atherosclerosis. In this article, we review current literature on pro-inflammatory activities of extracellular cyclophilins and discuss possible approaches to selectively target this novel proinflammatory factor.

Keywords: Extracellular cyclophilins, chemotaxis, inflammation, CD147, leukocytes, monocytes.

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Article Details

VOLUME: 19
ISSUE: 33
Year: 2013
Page: [5904 - 5908]
Pages: 5
DOI: 10.2174/1381612811319330009
Price: $58

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