Carbopol 934-P Loaded with Vildagliptin for Diabetic Delivery: In Vitro and In Vivo Evaluation of Nanoparticles
Sree Harsha N,
Bander E. Aldhubiab,
Ibrahim Abdulrahman Alhaider,
Vildagliptin-loaded mucoadhesive nanoparticles using Carbopol 934 P (CVN) as mucoadhesive polymer were prepared by
Buchi Nano Spray Dryer to retain the drug in the stomach for a prolonged period of time and to provide sustainable release. The morphological
properties of the nanoparticles were studied by scanning electron microscopy and found to have smoother surface with shriveled
shape. Drug loading and the percentage recovery werefound to be 89.2 ± 0.5 and 96 ± 0.4 respectively. Bimodal particle size distribution
with a mean of 355.8 nm and 80.15 nm was noticed. Angle of repose for CVN particles was relatively good with θ < 32.4°. The percent
swelling of CVN formulation was found to be 181±9%. In vivo studies in rats suggest that the vildagliptin was retained in the gastrointestinal
tract(GIT) for prolonged period of time (~12 h) and standard group was reduced significantly (~3 h). Stability studies witnessed no
changes when stored at 3-5°C or 15 – 25°C, except that the agglutinative phenomenon which was observed at 37°C and RH 75%. This
study validates the mucoadhesive nanoparticles as one of the most appropriate drug delivery approaches for the effective delivery of vildagliptin.
Keywords: Nanoparticles, vildagliptin, spraydrying, diabetic, carbopol, shriveled.
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