Current Nanoscience

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Silica/Ormosil SPIONs for Biomedical Applications

Author(s): M. C. Gonçalves, L. M. Fortes, A. R. Pimenta, J. C.G. Pereira, R. M. Almeida, M. D. Carvalho, L. P. Ferreira, M. M. Cruz, M. Godinho.

Abstract:

In the present work, magnetic nanoparticles coated with silica or ORMOSIL are prepared in a two step process. In the first step, SPIONs with 6 nm average diameter are produced by a reduction-precipitation process conducted in air and in the second one, SPIONs were used as seeds for silica/ORMOSIL growth (below 30 nm), in situ by a modified Stöber sol-gel method. SPIONs and silica/ ORMOSIL magnetic core-shell nanostructures were characterized by X-Ray diffraction (XRD), Fourier transformed infrared (FTIR) spectroscopy, transmission electron microscopy (TEM), Mössbauer spectroscopy and SQUID magnetometry. TEM observations of SPIONs and silica/ORMOSIL SPIONs allow determining size and shape. FTIR allows determining silica/ORMOSIL structural fingerprints. X-ray and Mössbauer spectroscopy allow determining the magnetite/maghemite ratio, discussed as a nanosized constrained. SPIONs and silica/ORMOSIL SPIONs show superparamagnetic properties making them appropriated to biomedical applications.

Keywords: Superparamagnetic iron oxide nanoparticles, SPIONs, silica/ORMOSIL coating, sol-gel, core-shell nanostructures.

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Article Details

VOLUME: 9
ISSUE: 5
Year: 2013
Page: [599 - 608]
Pages: 10
DOI: 10.2174/15734137113099990004
Price: $58