Nucleosides, a Valuable Chemical Marker for Quality Control in Traditional Chinese Medicine Cordyceps
Cordyceps, a well-known traditional Chinese medicine, is an endoparasitic and/or symbiotic macrofungus in
the body of insect and other arthropod, and has received increasing attention worldwide due to its rarity and outstanding
curative effects for different diseases. Recent years, however, the counterfeits and mimics of Cordyceps are frequently
found in markets because of its scarce in nature and high in price. Therefore, quality control of Cordyceps and its bioproducts
is very important to ensure their safety and efficacy. Nucleoside is recognized as a major active component of
Cordyceps, and even is used as chemical marker for quality control of Cordyceps. In this present review, recent studies
and associated patents, with regard to the chemical marker nucleosides for quality control of Cordyceps and its bioproducts,
including nucleoside components, pharmacological activities, and analytical methods were reviewed and discussed
thereof. Also, developing trends in the field have been appraised.
Keywords: Cordyceps, nucleoside, bioactivity, chemical marker, quality control.
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