Recent Patents on Biotechnology

Rongling Wu
Departments of Public Health Sciences and Statistics
Pennsylvania State College of Medicine
Hershey, PA
USA

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Protein Microarrays: Technological Aspects, Applications and Intellectual Property

Author(s): Noelia Dasilva, Paula Díez, María González-González, Sergio Matarraz, J. M. Sayagués, Alberto Orfao and Manuel Fuentes

Affiliation: Centro de Investigación del Cáncer/IBMCC (USAL/CSIC), IBSAL, Departamento de Medicina and Servicio General de Citometría, University of Salamanca, Salamanca 37007, Spain.

Keywords: Antibody, biomarker, capture agent, detection strategy, epitope, fluorochrome, high throughput, ligand, patent, protein microarray, proteomics, reverse phase array, substrate, surface functionalization, target protein.

Abstract:

Over the last decade, proteomics has undergone remarkable progress thanks to the technical advances made in the field. Improvements in the design of the protein microarrays, including more types of chemical groups for surface functionalization, new capture agents and novel detection strategies, among others, have allowed the detection of proteins in a robust, specific, sensitive, real time and high throughput manner. However, there are still problems that hinder the analysis of low abundance proteins or those present in complex samples. For this reason, the development of patents related to the features mentioned above has an important relevance. In this review, we focus on the study of recently approved patents that try to solve the existing problems. Thanks to them, it is expected that the identification of disease biomarkers can be made in a suitable and reliable way, and above all, biocompatible and environmentally friendly.

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Article Details

VOLUME: 7
ISSUE: 2
Page: [142 - 152]
Pages: 11
DOI: 10.2174/18722083113079990007