Cardiovascular & Hematological Disorders-Drug Targets

(Formerly Current Drug Targets - Cardiovascular & Hematological Disorders)

Garry X. Shen  
University of Manitoba
Winnipeg, MB


Oxidative Stress and Transforming Growth Factor-β1-induced Cardiac Fibrosis

Author(s): Yudi Purnomo, Yvette Piccart, Tamara Coenen, John S. Prihadi and Paul J. Lijnen

Affiliation: Hypertension Unit, Campus Gasthuisberg, Herestraat 49 Box 702, B-3000 Leuven, Belgium.


A chronic increase in reactive oxygen species (ROS) plays a critical role in the development and progression of cardiac remodeling associated with heart failure. Oxidative stress is indeed increased in heart failure, hypertension, cardiac fibrosis and hypertrophy. In vitro exposure of cardiac fibroblasts to superoxide anion stimulates their proliferation by increasing the production of transforming growth factor-β1 (TGF-β1), a potent fibrogenic cytokine. TGF-β1 plays an important role in cardiac development, cardiac hypertrophy, ventricular remodeling and the early response to myocardial infarction. In this review the role of TGF-β1 and ROS in the production and deposition of collagens by cardiac fibroblasts and in the induction of gene expression in relation to the development of myocardial fibrosis and to myocardial tissue repair will be discussed.

Keywords: Transforming growth factor-beta1, reactive oxygen species, collagen, cardiac fibrosis.

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Article Details

Page: [165 - 172]
Pages: 8
DOI: 10.2174/1871529X11313020010