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Cardiovascular & Hematological Disorders-Drug Targets
(Formerly Current Drug Targets - Cardiovascular & Hematological Disorders)
ISSN (Print): 1871-529X
ISSN (Online): 2212-4063
VOLUME: 13
ISSUE: 2
DOI: 10.2174/1871529X11313020010      Price:  $58









Oxidative Stress and Transforming Growth Factor-β1-induced Cardiac Fibrosis

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Author(s): Yudi Purnomo, Yvette Piccart, Tamara Coenen, John S. Prihadi and Paul J. Lijnen
Pages 165-172 (8)
Abstract:
A chronic increase in reactive oxygen species (ROS) plays a critical role in the development and progression of cardiac remodeling associated with heart failure. Oxidative stress is indeed increased in heart failure, hypertension, cardiac fibrosis and hypertrophy. In vitro exposure of cardiac fibroblasts to superoxide anion stimulates their proliferation by increasing the production of transforming growth factor-β1 (TGF-β1), a potent fibrogenic cytokine. TGF-β1 plays an important role in cardiac development, cardiac hypertrophy, ventricular remodeling and the early response to myocardial infarction. In this review the role of TGF-β1 and ROS in the production and deposition of collagens by cardiac fibroblasts and in the induction of gene expression in relation to the development of myocardial fibrosis and to myocardial tissue repair will be discussed.
Keywords:
Transforming growth factor-beta1, reactive oxygen species, collagen, cardiac fibrosis.
Affiliation:
Hypertension Unit, Campus Gasthuisberg, Herestraat 49 Box 702, B-3000 Leuven, Belgium.