Anxiety: A Systematic Review of Neurobiology, Traditional Pharmaceuticals and Novel Alternatives from Medicinal Plants
Erica Aparecida Gelfuso, Daiane Santos Rosa, Ana Lúcia Fachin, Márcia Renata Mortari, Alexandra Olimpio Siqueira Cunha and Rene Oliveira Beleboni
Affiliation: Av. Constabile Romano, 2201, Biotechnology Unity, UNAERP; Ribeirao Preto- SP, 14096-900, Brazil.
Keywords: Anxiety, anxiolytics, botanicals, pharmacology, neurobiology, herbal medicines.
Pathologic anxiety is a disproportional reaction of individuals to anticipation or misinterpretation of a potential
danger, which affects individual social and personal life. Despite the advances already accomplished, further studies are
still necessary in order to understand the mechanisms involved in anxiety. These may provide more effective and safer
treatments to aid in the control of anxiety and improve patient quality of life. In this work, we review the current issue
about anxiety disorders, covering general aspects such as basic epidemiology and classification, an overview of the
pharmacological treatments employed and the current search for natural anxiolytics. Also, a compilation of data
investigating the neurobiology that underlies anxiety disorders and a brief discussion evolving the most usual animal
experimental models to study anxiety is presented.
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