In this study, antidepressant-like effects of intra-cerebroventricularly administration of oxoisoaporphine derivatives
in post stroke-depressive like behavior were examined through despair swimming and tail suspension models. For
this aim, acute ischemic stroke was induced by bilateral common carotid arteries occlusion which significantly changed
the normal behaviors of male balb/c mice. We performed stroke-induced anhedonia test as a key result of post strokedepressive
like behavior by determination of sucrose consumption. Results show that some 2,3-dihydro- and oxoisoaporphine
derivatives modified the abnormality in the behaviors through decreasing in the immobility time in tail suspension
and despair swimming models and increasing in the swimming and climbing times in despair swimming model. We concluded
that these alkaloids showed antidepressant actions and therefore can be used for treatment of post strokedepressive
like behavior in acute ischemic stroke patients.
Keywords: Oxoisoaporphine, antidepressant, depressive-like behavior, acute ischemic stroke.
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