Tumor-Targeting Peptides and Small Molecules as Anti-Cancer Agents to Overcome Drug Resistance

Author(s): Ehsan Sarafraz-Yazdi, Matthew R. Pincus, Josef Michl.

Journal Name: Current Medicinal Chemistry

Volume 21 , Issue 14 , 2014

Abstract:

Since the introduction of chemotherapy in cancer therapy, development of resistance to every new therapeutic has been the universal experience. The growing understanding of cancer genomics, cancer-associated signal transduction pathways, and key protein drivers of cancer has enabled cancer biologists and medicinal chemists to develop targeted molecules to interfere with these pathways to tackle drug resistant cancers. However, to the dismay of oncologists, the clinical use of many of these tools has once again brought to the forefront the inevitable challenge of drug resistance. It is now understood that cancer resistance to different therapies involves multiple challenges that encompass the cancer cell itself as well as host physiology. This review presents small molecule inhibitors and peptides as two therapeutic approaches in anti-cancer drug development. Resistance to selected samples of these novel therapies is described in the context of cell autonomous resistance, the contributions of the tumor microenvironment, and germ line factors. For each approach, advantages and disadvantages are discussed on how to better overcome the inevitable challenge of resistance in cancer treatment.

Keywords: Anti-cancer peptides, drug resistance, small molecule inhibitors, targeted cancer therapy.

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Article Details

VOLUME: 21
ISSUE: 14
Year: 2014
Page: [1618 - 1630]
Pages: 13
DOI: 10.2174/09298673113209990223
Price: $58

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