Background: Paracetamol (acetaminophen) is a widely used analgesic/antipyretic drug for which hypersensitivity
reactions appear to be increasingly frequent. Objective: We report the case of a woman who experienced several delayed
selective reactions induced by paracetamol: fixed drug eruptions (FDEs) with typical features but an unusual distribution
(hard palate and a maculopapular rash. Methods: Skin tests: prick, intradermal and patch tests as well as a single-blind
oral challenge test (OCT) were performed. Results: Skin tests were negative. The OCT was necessary to confirm the diagnosis.
Interestingly, the challenge test elicited an FDE-type lesion instead of a maculopapular rash. Conclusions: Our findings
could reflect 2 different clinical patterns of delayed allergic reactions, or, more probably, the initial phase of a unique
clinical entity that was stopped by the corticosteroids prescribed during the challenge. However, we were unable to confirm
these hypotheses. The uncommon anatomical site of the lesions (hard palate) is noteworthy. Some relevant patents
are also summarized in this paper.