Liposomes as Potential Carrier System for Targeted Delivery of Polyene Antibiotics
Suresh R. Naik, Sandhya K. Desai, Priyank D. Shah and Santosh M. Wala
Affiliation: Department of Pharmacology, Sinhgad Institute of Pharmaceutical Sciences, Gat No. 309, off Mumbai- Pune Expressway, Kusgaon (Bk.), Lonavala-410401, Dist: Pune, Maharashtra, India.
The development of new therapeutic modalities involves the use of drug carrier, such as liposomes, which can
modify pharmacokinetic and bio-distribution of drug profile. Polyene antibiotics incorporation into liposomes improves
its availability at the site, bio-distribution and therapeutic index mainly through the engulfment of liposomes by circulating
monocytes/macrophages and transportation to the site of infection. Polyene antibiotics (AmB, SJA-95, HA-1-92) and
other antibiotics (streptomycin, tobramycin, quinolones, anti-tubercular and anti-cancer drugs), liposomal preparations are
described with possible advantages from therapeutic efficacy and toxicity point of view. The polyene macrolide antibiotics
liposomal preparations proved to be more effective in the treatment of systemic mycosis. The AmB-cyclodextrin derivatives
inclusion complex is a major breakthrough in liposomal preparation which can be converted into aqueous phase
of liposome. Liposomal drug incorporated preparation has been one of the important areas of research for developing the
existing polyene antibiotics into useful chemotherapeutic agents in clinical medicine. In recent past other antibiotics have
also been incorporated into liposomes using wide variety of materials, phosphatidylethanolamine derivatives (pegylated
liposomes, enzyme sensitive conjugates, fluidosomes of anti-cancer drugs and poly lactic/glycolic acid microspheres for
anti-tuberculosis drugs). In addition, attempts were also made to extend the receptor mediated drug targeting and to review
some relevant patents.
Keywords: Chemotherapeutic activity, decreased toxicity, liposomes, pharmacokinetics, polyene antibiotics.
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