Abstract
Although Mycobacterium tuberculosis infection remains a global killer, many immunopathological aspects of the disease are poorly understood, and defence mechanisms long thought to help host defences such as granuloma formation have recently been challenged. This review highlights contemporary evidence that granulomas may benefit mycobacterial survival and dissemination, particularly citing the zebrafish model of pathogenesis. Other selected examples of novel research covered include the role of the lung extracellular matrix, mycobacterial evasion techniques, chemokine response, immune reconstitution in the context of human immunodeficiency virus, and biomarker development. These advances may yield improved diagnostics and offer targets for anti-tuberculous chemotherapy and vaccine development.
Keywords: Granuloma, immunology, pathology, paradigm, review, tuberculosis, zebrafish.
Current Respiratory Medicine Reviews
Title:The Immunopathology of Tuberculosis – An Update
Volume: 9 Issue: 3
Author(s): Colin S. Brown and Nicholas M. Price
Affiliation:
Keywords: Granuloma, immunology, pathology, paradigm, review, tuberculosis, zebrafish.
Abstract: Although Mycobacterium tuberculosis infection remains a global killer, many immunopathological aspects of the disease are poorly understood, and defence mechanisms long thought to help host defences such as granuloma formation have recently been challenged. This review highlights contemporary evidence that granulomas may benefit mycobacterial survival and dissemination, particularly citing the zebrafish model of pathogenesis. Other selected examples of novel research covered include the role of the lung extracellular matrix, mycobacterial evasion techniques, chemokine response, immune reconstitution in the context of human immunodeficiency virus, and biomarker development. These advances may yield improved diagnostics and offer targets for anti-tuberculous chemotherapy and vaccine development.
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Cite this article as:
Brown S. Colin and Price M. Nicholas, The Immunopathology of Tuberculosis – An Update, Current Respiratory Medicine Reviews 2013; 9 (3) . https://dx.doi.org/10.2174/1573398X113099990020
DOI https://dx.doi.org/10.2174/1573398X113099990020 |
Print ISSN 1573-398X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6387 |
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