The Immunopathology of Tuberculosis – An Update
Colin S. Brown,
Nicholas M. Price.
Although Mycobacterium tuberculosis infection remains a global killer, many immunopathological aspects of
the disease are poorly understood, and defence mechanisms long thought to help host defences such as granuloma
formation have recently been challenged. This review highlights contemporary evidence that granulomas may benefit
mycobacterial survival and dissemination, particularly citing the zebrafish model of pathogenesis. Other selected
examples of novel research covered include the role of the lung extracellular matrix, mycobacterial evasion techniques,
chemokine response, immune reconstitution in the context of human immunodeficiency virus, and biomarker
development. These advances may yield improved diagnostics and offer targets for anti-tuberculous chemotherapy and
Keywords: Granuloma, immunology, pathology, paradigm, review, tuberculosis, zebrafish.
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